Acrodisc® Syringe Filters Optimized for Scale Up

Devices Constructed of the Same Materials
as Larger-Capacity Capsules and Cartridges

• Simplifies scale-up and minimizes revalidation; no need to change membrane materials during transition to pilot or production.
• Four membrane chemistries assure compatibility with a wide range of fluids:
  • Supor® membrane has high flow rates and throughputs, and is ideal for solutions where low protein binding is required. Not recommended with some ketones.
  • Fluorodyne® II membrane offers high flow rates and is ideal for applications where PVDF membrane is specified. Not recommended with some ethers.
  • Ultipor® membrane provides broad solvent and chemical compatibility, and low extractables.
  • Posidyne® membrane enhances bioburden and pyrogen removal from aqueous solutions.
• Integrity testable (water bubble point).
• Bacterial retention tested.
• Sterilized by gamma irradiation to eliminate potential contamination by EtO residuals.

• Drug development studies
• Determination of product compatibility and recovery
• Preliminary filterability testing
• Small-volume liquid sterilization

Materials of Construction

• Filter Media: Supor [hydrophilic polyethersulfone (PES)], Fluorodyne II (hydrophilic PVDF), Ultipor (Nylon 6,6), and Posidyne (positively-charged Nylon 6,6) membranes
• Housing: Polypropylene

Effective Filtration Area

• 2.8 cm²

Inlet/Outlet Connections

• Female luer lock inlet, male slip luer outlet

Typical Hold-Up Volume

• < 100 μL

Maximum Operating Temperature

• 60 °C (140 °F) at 2.1 bar (210 kPa, 30 psi)

Maximum Operating Pressure

• 5.4 bar (540 kPa, 80 psi) at ambient temperature

Typical Water Flow Rate

• mL/min at 2.1 bar (210 kPa, 30 psi)
• PN 4905: 130
• PN 4906: 78
• PN 4907: 130
• PN 4908: 77

Recommended Integrity Test Minimum Bubble Point - Water

• PN 4905: 3.5 bar (350 kPa, 51 psi)
• PN 4906, 4908, and 4907: 3.2 bar (320 kPa, 46 psi)
• PN 4902: 3.32 bar (332 kPa, 48 psi)

Bacterial Retention

• Lot samples retain a minimum of 10⁷ cfu/cm² of B. diminuta per modified ASTM F838-05, current revision

Endotoxin Level

• < 0.25 EU/mL using Limulus Amoebocyte Lysate (LAL) test

Biological Safety

• Passes United States Pharmacopeia (USP) Biological Reactivity Test, In Vivo <88>

Sterilization

• Sterilized by gamma irradiation and individually packaged

• AcroPak™ 20 Filters with Supor® Membrane
• AcroPak™ 200 Capsules with Supor® Membranes
• AcroPak™ 500, 1000, & 1500 Capsules with Supor® Membrane
• AcroPak™ 20 Filters and AcroPak 200 Capsule with Fluorodyne® II Membrane
• AcroPak™ 400 and 800 Capsules with Fluorodyne® II Membrane

Part Number	Description	Pkg	Price	Qty
Acrodisc® Syringe Filters, 25 mm
4905	0.8/0.2 µm, Supor membrane, sterile	50/pkg	191.10
4907	0.2 µm, Fluorodyne II membrane, sterile	50/pkg	191.10
4906	0.2 µm, Ultipor membrane, sterile	50/pkg	191.10
4908	0.2 µm, Posidyne membrane, sterile	50/pkg	191.10
4902	MachV asymmetric prefilter/0.2 µm Supor EKV membrane, sterile	50/pkg	219.51

Contact Customer Service at 800-521-1520 for possible lead-time and ship date.