LV Centramate™ Lab Tangential Flow Filtration System

Designed for Maximum Product Recovery for
Lab-Scale or Scale-Up Process Volumes up to 4 L

• Scale-up/scale-down device for development of tangential flow filtration (TFF) processes, biopharmaceutical small batch production, scale-down investigations, and production of materials for safety and efficacy studies (Phase I clinicals).
• Identical path lengths provide linear scale-up to Pall Centramate and Centrasette™ cassette holders. The LV Centramate holder may be attached to other laboratory TFF systems to improve their scalability characteristics.
• Low hold-up volume allows high concentration factors to be achieved from small starting volumes. A complete TFF system scalable to full production plant can be optimized using the volumes typically generated in the development or discovery lab.
• Easy connections through luer lock fitted ports with polished 316L stainless steel to ensure the same compatibility characteristics as production-scale Centrasette holders.
• All product-wetted parts comply with pharmaceutical standards.

• Concentration of biomolecules
• Recovery and purification of biomolecules from cell culture supernatants and lysates
• Diafiltration, desalting, and buffer exchange of biomolecules
• Fractionation of mixed molecule solutions

Materials of Construction

• Membrane Cassette Filter Media: Supor® [hydrophilic polyethersulfone (PES)], and Omega™ (low protein-binding, modified PES) membranes
• Cassette Hardware
• Cassette Holder Top and Bottom Plates: Type 316L stainless steel
• Tie Rods and Washers: Type 304 stainless steel
• Nuts: Bronze

Dimensions

• Length: 22.8 cm (9 in.) Width: 8.3 cm (3.3 in.)

Typical Starting Volume

• 0.02 m² (0.2 ft²) cassette: 60 - 4,000 mL

Typical Hold-Up Volume

• < 1 mL

Maximum Operating Temperature

• 121 °C (250 °F)

Maximum Operating Pressure

• 5 bar (500 kPa, 75 psi)

Typical Cross Flow Rate Per 0.02 m² (0.2 ft²) Cassette (L/min)

• Suspended Screen 0.2 - 0.4
• Screen 0.12 - 0.16

Screen Selection Guideline

• Suspended screen for light-tomoderate particle load solutions
• Screen for optimized processing of particle-free protein solutions to high concentrations

Part Number	Description	Pkg	Price	Qty
LV Centramate™ Cassette Holder
CM018LV	LV Centramate cassette holder	1/pkg	2,933.37
Replacement Parts
FS007X01	Bronze nuts and washers	4/pkg	165.67
Supor® Membrane LV Centramate™ Cassettes
PSM10C11P2	0.1 µm, 0.02 m2 (0.2 ft.2) suspended screen	1/pkg	352.56
PSM10C12P2	0.1 µm, 0.02 m2, (0.2 ft.2), medium screen	1/pkg	352.56
PSM20C11P2	0.2 µm, 0.02 m2 (0.2 ft.2), suspended screen	1/pkg	352.56
PSM20C12P2	0.2 µm, 0.02 m2 (0.2 ft.2), medium screen	1/pkg	352.56
PSM45C11P2	0.45 µm, 0.02 m2 (0.2 ft.2), suspended screen	1/pkg	352.56
PSM45C12P2	0.45 µm, 0.02 m2 (0.2 ft.2), medium screen	1/pkg	352.56
PSM65C11P2	0.65 µm, 0.02 m2 (0.2 ft.2), suspended screen	1/pkg	352.56
PSM65C12P2	0.65 µm, 0.02 m2 (0.2 ft.2), medium screen	1/pkg	352.56
Omega™ Membrane LV Centramate™ Cassettes
OS001C11P2	1K, 0.02 m2 (0.2 ft.2), suspended screen	1/pkg	352.56
OS001T02	1K, 0.02 m2 (0.2 ft.2), screen	1/pkg	346.32
OS005C11P2	5K, 0.02 m2 (0.2 ft.2), suspended screen	1/pkg	352.56
OS005T02	5K, 0.02 m2 (0.2 ft.2), screen	1/pkg	346.32
OS010T02	10K, 0.02 m2 (0.2 ft.2), screen	1/pkg	346.32
OS030C11P2	30K, 0.02 m2 (0.2 ft.2), suspended screen	1/pkg	352.56
OS030T02	30K, 0.02 m2 (0.2 ft.2), screen	1/pkg	346.32
OS050C11P2	50K, 0.02 m2 (0.2 ft.2), suspended screen	1/pkg	352.56
OS050T02	50K, 0.02 m2 (0.2 ft.2), screen	1/pkg	346.32
OS070T02	70K, 0.02 m2 (0.2 ft.2), screen	1/pkg	346.32
OS100T02	100K, 0.02 m2 (0.2 ft.2), screen	1/pkg	346.32
OS300C11P2	300K, 0.02 m2 (0.2 ft.2), suspended screen	1/pkg	352.56
OS300T02	300K, 0.02 m2 (0.2 ft.2), screen	1/pkg	346.32

Contact Customer Service at 800-521-1520 for possible lead-time and ship date.